The inability to effectively cope with stress brings about numerous physical and psychological disorders. Alternative methods of coping with stress are important to examine, but there is a lack of awareness and acceptance of non-Western spiritual practices within the general public and mainstream scientific domains. Due to limited research on the ritual use of ayahuasca as part of the means to cope and thrive in daily life, conventional assumptions about its status as an illegal substance negatively alters its interpretation as an effective therapeutic aid. This phenomenological study was an investigation of the spiritual experience of participants of the Santo Daime Church, a syncretic religious group that uses ayahuasca as their sacrament. The purpose of this study was to explore the experience of spiritual guidance to enhance coping strategies and reduce stress. The theoretical lens of holism, which holds that individuals are best understood as a function of their social, physical, mental, emotional, and spiritual contexts, informed this study. From the population of approximately 60 local church members, 14 individuals volunteered to participate in semi structured interviews. The resulting transcripts were analyzed using the method of Interpretative Phenomenological Analysis to uncover themes within and across cases. Overall, 6 themes and 53 subthemes were identified. The 6 primary themes included: The Trial, Ecstatic Spiritual Communion, Supernatural Contact, Rapture, Macroscopic Kinship, and Enhanced Coping. The results of this study may impact conventional assumptions regarding the potential of mind-altering substances as effective therapeutic aids. Positive social change may result when health professionals consider expanded alternatives for therapeutic tools to help clients cope effectively with stress.