New psychoactive substances (NPS) have become increasingly popular, despite the potential harm associated with their use. Due to its unknown profile, it is of vital importance that any toxicological data collected is shared, in order to understand the effects associated with the use of these substances, and this data are shared with the scientific community in order to update the knowledge available. This report deals has two objectives. The first one is to focus on the toxicological effects and health risks linked to the use of NPS. The second one is to provide information for forensic toxicologists in cases where an NPS has been identified and may have been involved in the cause of death.