Over 140 beta-carboline (Harmala) alkaloids are detected in bacteria, algae, fungi, various plant groups, food products, alcoholic beverages, tobacco smoke, marine bryozoa, insects, and animal tissue including human. Some of these alkaloids and their derivatives are synthesized chemically. Several natural and chemically formed alkaloids are biologically active, and they can be used as potent pharmaceutical drug for anticancer therapy, angiogenesis, Alzheimer’s, free radical scavenger, Leishmania, and viruses Herpes, Influenza, Polio, and HIV.