Sexual abuse and misconduct towards female participants in ayahuasca circles are, unfortunately, quite prevalent. Exact numbers are difficult to obtain, as most cases never come to light; nonetheless, the issue is common knowledge within the ayahuasca community. As an organization dedicated to providing public education and cultural understanding about plant medicines, we at the Chacruna Institute for Psychedelic Plant Medicines do not wish to dissuade women from drinking ayahuasca, but rather to raise awareness about sexual harassment, and offer practical guidelines in the interest of keeping female participants in ayahuasca ceremonies and communities safe. While our guide is aimed toward preventing female participant abuse by male shamans, where the most commonplace abuses have occurred, we also acknowledge that abuse happens by and toward other genders. This guide embraces a culturally-sensitive approach toward raising awareness and the avoidance of abuse in typical scenarios without diminishing the fact that abuse is unlawful and unacceptable in all circumstances.