Jorge Ochavano Vasquez, also known as Soi, is a Shipibo onaya (“one who knows”: a healer who works with oni, meaning wisdom or knowledge, the Shipibo name for ayahuasca) from the Ucayali River Basin in the Peruvian Amazon. Heir to a long line of Shipibo onayabo, he was initiated into this medical system while growing up in a region of rainforest undergoing rapid globalization and urbanization. Soi belongs to a generation of young Shipibo healers whose practice has been heavily informed and influenced by the increasing interest, attention, and presence of Western ayahuasca seekers. Working regularly in retreat centers that cater to Western clients (including the Temple of the Way of Light as well as his own family center in the native community of Nueva Betania). In this interview, we explore Soi’s perception of illness and well-being as it emerges from the encounter between two worldviews and their related medical systems. Amazonian diagnostic categories such as “daño,” “susto,” or “cupia”—some of the most common complaints among indigenous or mestizo Amazonians—imply a degree of external agency and are usually attributed to sorcery, magic, or disharmonious relationships with the plant, animal, or spirit realms. Yet, the majority of Westerners seeking ayahuasca usually complain of depression, anxiety, posttraumatic symptoms, and a variety of other self-reported experiences that, whether as diagnostic constructs or subjective narratives of affliction, are mostly prevalent in industrialized and individualistic societies. In this interview, we offer the perspective of a young healer, who dialogues with both indigenous etiologies and Western diagnostic constructs, working on the frontline of the controversies surrounding the tension between tradition and innovation, and who has lived experience of the paradoxical nature of “development” in a rapidly Westernizing world.