The current article examines the nature of the contributions to the Ayahuasca Track and note the mix of persons, from research scientists to shamans, including many seekers of healing and spiri- tual experience, interested in the topic. We draw an overview of the track debates, and ideas that perhaps deserve more space are con- sidered, and notable presentations are discussed. Finally, we reflect on the ethical, political and methodological challenges involved in research with ayahuasca. We hope that this text will provide a use- ful review of the current state of research in the field of ayahuasca studies.