Peganum harmala L. Commonly known as Syrian rue, Wild rue or Harmal is native to arid and semi-arid regions of Northern African and Asian deserts that have spread to parts of the southwestern United States and Northern Mexico. It is a multipurpose medicinal plant with antimicrobial, antifungal, anti-inflammatory, antidiabetic, anti cancerous, hypothermic and hallucinogenic activities. Phytochemical investigations has revealed the presences of a number of active alkaloids especially beta-carbolines such as harmalol, harmaline, and harmine. Seeds and roots contain the highest levels of alkaloids with low level in stem and leaves and absent in flowers. This emphasizes on the need of widespread study for covering the supplementary information on the medicinal importance of other species of genus peganum.