The multiple cultural and ethnopharmacological uses of DMT in combination with harmala alkaloids has generally been regarded as safe with a low potential for addiction. While DMT is also produced endogenously, it appears to present with multiple physiological and pharmacological activities that may serve as a lead pharmacophore for further investigations. It is clear from this discussion that DMT and other alkaloids with hallucinogenic potential warrant further observation and clinical studies under the guidance of a health care professional and proper dosing recommendations.