In the experiments reported in this paper we used a moderately long (5 set) and constant conditioned stimulus-unconditioned stimulus interval. According to the reaction time data, where schizophrenics show the greatest defect under conditions of a long and regular preparatory interval, it may be a worthy approach to determine whether DMT produces the greatest degree of disruption on the conditioned avoidance response using a long and constant conditioned stimulus-unconditioned stimulus interval. More precisely, the conditioned stimulus-unconditioned stimulus interval can be an experimental analogue of the preparatory interval if we employed discriminative and sequential conditioned stimuli before the unconditioned stimulus; both stimuli would serve as a signal but the first conditioned stimulus prepares the rat to respond (shuttle responses are prevented during its presentation) and the second conditioned stimulus allows the rat to respond. Regarding stereotypy and its possible relationship to attention, clinical observations suggest that schizophrenics have a tendency to routinize and automatize their response to situations. This might have the adaptative effect of making it easier for the schizophrenic to reduce the stimulus overload. However, at the same time, the schizophrenic may remain glued to the same sector forever, interfering with the ability to shift attention to other relevant stimuli via some switch mechanism. Stereotypy in schizophrenics as well as in animals may be related to this disturbance in shifting attention from one stimulus to another in that the organism remains fixated, perseverating its responses on a particular stimulus complex, at the exclusion of all others. The two models given here are particularly germane because they deal with substances which are potential endogenous agents of schizophrenia. Further research may show that DMT or PEA are a “will-o-the-wisp.” Nonetheless, the use of animal models in psychiatry will increase our understanding of the biological mechanisms underlying behavior, the mode of action of drugs and perhaps even schizophrenia.