Cohoba, a narcotic snuff which the aboriginal inhabitants of Haiti took by means of a bifurcated tube, has hitherto been regarded by most writers as a form of tobacco. It was, however, prepared from the seeds of a Mimosa-like tree, Piptaenia peregrina. This tree is widely spread in South America, and by several tribes of Indians its seeds are used, or have been used until recently, as a source of snuff, the effects of which are highly intoxicating. Among several of these tribes the snuffing tubes are bifurcated and very similar to those of the ancient Haitians. The source of the snuff on the island of Haiti has remained unknown for so long a time on account of the early annihilation of the aborigines and their replacement by Africans, who did not adopt the habit of snuffing. The most remarkable fact connected with Piptadenia peregrina, or "tree-tobacco," is that, though its fruit has been reported by many explorers and botanists as highly narcotic, it has never been studied chemically or therapeutically, and the source of its intoxicating properties still remains unknown. Abundant material may be obtained from the island of Porto Rico, where the tree is common, and it is hoped that a careful study may be made of the seeds, the peculiar properties of which were noticed in the very first work which treated of the ethnology of the New World.